Video tour
Watch a video tour of our Laboratory of Bioinformatics and Biostatistics.
Laboratory of Bioinformatics and Biostatistics is dedicated to:
In the field of clinical bioinformatics, the laboratory, in cooperation with the Clinic of
Gynecology and Obstetrics and the Institute of Molecular Biology and Genomics, participated
in implementation of non-invasive prenatal screening (NIPS) at JFMED CU, and improvements of bioinformatics of NIPS.
In close cooperation with the Institute of Molecular Biology and Genomics JFMED CU, the laboratory takes part in oncological research projects involving NGS sequencing (DNAseq, RNAseq).
Under the supervision of the Institute of Pathological Anatomy of JFMED CU, the laboratory
participates in introducing the TSO 500 panel for genomic profiling of oncological samples. Biostatistical analyses are also used in research projects of other laboratories of BioMed, institutes of JFMED CU, and the clinics of Martin University Hospital. In addition to basic and advanced statistical methods, data analysis process also uses, if appropriate, machine
learning (ML) algorithms. Machine learning is also used for prioritization of biomarkers in omics studies.
The laboratory is equipped with an iCompute server and DELL servers. The laboratory caries out bioinformatic analyses using an in-house statistical pipeline which were developed with the assistance of the BioConductor libraries and R, as well as other bioinformatic tools. In cooperation with the Institute of Molecular Biology and Genomics, the laboratory also applies the Qiagen CLC Workbench for NGS analyses. The R software tool is used for biostatistical analyses and machine learning.
Take a virtual tour of our modern Laboratory of Bioinformatics and Biostatistics.
ITMS 313011V446, „Integrative strategy for development of personalized medicine of selected oncological diseases and its impact on quality of patient´s life.“
ITMS NFP313010AFG5, „Systematic public research infrastructure – biobank for oncological and rare diseases. “
ITMS 313011AUA4, „New methods of laboratory diagnostics and massive screening of
SARS-Cov-2, and identifying the mechanisms of virus behavior in the human body”
ITMS 313011AFG4, „Digital biobank. “
APVV-16-0066, „Genomic profiling and transcriptional signature of colorectal cancer. “ (project manager: Assoc.prof. Lasabova, Institute of Molecular Biology and Genomics, JFMED CU).
APVV-17-0037, „Development of new in vitro models for amyotrophic lateral sclerosis and testing the safety of neural precursors derived from human induced pluripotent stem cells. “ (project manager Dr. J. Strnádel, Laboratory of Flow Cytometry, Cell Phenotyping and Tissue Engineering, BioMed JFMED CU.
APVV-19-0222, „Determination of mitochondrial fitness in diagnostics and prediction of Parkinson´s disease. “ (PI, M. Kolisek, Laboratory of Proteomics and Mitochondriopathies, BioMed JFMED CU).
Ministry of Health SR 2018/11-UKMT-7, „Biogenic iron oxides as biomarkers of neurodegenerative diseases mapped by advanced methods of magnetic resonance. “ (PI, Dr. O. Štrbák, Metabolomics Laboratory, BioMed JFMED CU).
COST CA17118, „Identifying Biomarkers Through Translational Research for Prevention and Stratification of Colorectal Cancer. “ ( , Z. Lasabova, Institute of Molecular Biology and Genomics).
Stančík M, Grendár M, Mokáň M. Carboxypeptidase B1 in dialyzed chronic kidney disease patients. Scientific Reports. 2025 Feb 4;15(1):1-0.
Kolkova Z, Suroviakova S, Grendar M, Havlicekova Z, Hornakova A, Holubekova V, Halasova E, Banovcin P. Altered miRNA expression in duodenal tissue of celiac patients and the impact of a gluten-free diet: a preliminary study. Molecular Biology Reports. 2025 Dec;52(1):1-2.
Bielik V, Nosáľ V, Nechalová L, Špánik M, Žilková K, Grendar M. The prediction model of academic achievement based on cardiorespiratory fitness and BMI status for ninth-grade students. BMC pediatrics. 2025 Jan 9;25(1):20.
Schniederova M, Bobcakova A, Grendar M, Markocsy A, Ceres A, Cibulka M, Dobrota D, Jesenak M. Lymphocyte Inhibition Mechanisms and Immune Checkpoints in COVID-19: Insights into Prognostic Markers and Disease Severity. Medicina. 2025 Jan 22;61(2):189.
Loderer D, Hornáková A, Tobiášová K, Lešková K, Halašová E, Danková Z, Biringer K, Kúdela E, Rokos T, Dzian A, Miklušica J. Comparison of next‑generation sequencing quality metrics and concordance in the detection of cancer‑specific molecular alterations between formalin‑fixed paraffin‑embedded and fresh‑frozen samples in comprehensive genomic profiling with the Illumina® TruSight Oncology 500 assay. Experimental and Therapeutic Medicine. 2025 Apr 1;29(4):1-4.
Škodová Z, Ďuríčeková B, Bánovčinová Ľ, Urbanová E, Bašková M, Grendár M. Factor structure and psychometric characteristics of the City birth Trauma Scale-Slovak version. Sexual & Reproductive Healthcare. 2025 Mar 1;43:101063.
Lucanska M, Calkovsky V, Grendar M, Neuschlova M, Samec M, Kunc P, Pecova R. Changes of the cough reflex sensitivity following the septoplasty. Acta Oto-Laryngologica. 2025 Apr 22:1-3.
Sivoňová MK, Híveš M, Kliment J, Dušenka R, Grendár M, Evin D, Kaplán P, Brožová MK, Vilčková M, Vondrák A, Jurečeková J. Genetic alterations of Cyclin D-CDK4/6-INK4-RB pathway in prostate cancer. Molecular Biology Reports. 2025 Dec;52(1):1-0.
Vyšehradský P, Solovič I, Kotúľová L, Grendár M, Rákošová M, Hudečková H, Vyšehradský R. Social differences between the general population and tuberculosis patients in Slovakia. Frontiers in Public Health. 2025 Feb 28;13:1541882.
Hnilicova P, Grendar M, Turcanova Koprusakova M, Trancikova Kralova A, Harsanyiova J, Krssak M, Just I, Misovicova N, Hikkelova M, Grossmann J, Spalek P. Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies. Scientific Reports. 2024 Aug 20;14(1):19267.
Babalova L, Grendar M, Kurca E, Sivak S, Kantorova E, Mikulova K, Stastny P, Fasko P, Szaboova K, Kubatka P, Nosal S. Forecasting extremely high ischemic stroke incidence using meteorological time serie. PloS one. 2024 Sep 11;19(9):e0310018.
Lukacova E, Hanzlikova Z, Podlesnyi P, Sedlackova T, Szemes T, Grendar M, Samec M, Hurtova T, Malicherova B, Leskova K, Budis J. Novel liquid biopsy CNV biomarkers in malignant melanoma. Scientific Reports. 2024 Jul 9;14(1):15786.
Brodnanova M, Cibulka M, Grendar M, Gondas E, Kolisek M. IL-6 Does Not Influence the Expression of SLC41A1 and Other Mg-Homeostatic Factors. International Journal of Molecular Sciences. 2024 Dec 11;25(24):13274.
Tobiášová K, Barthová M, Janáková Ľ, Lešková K, Farkašová A, Loderer D, Grendár M, Plank L. Discordant ALK Status in Non-Small Cell Lung Carcinoma: A Detailed Reevaluation Comparing IHC, FISH, and NGS Analyses. International Journal of Molecular Sciences. 2024 Jul 26;25(15):8168.
Števík M, Malík M, Vetešková Š, Trabalková Z, Hliboký M, Kolárik M, Magyar J, Bundzel M, Szabóová M, Babič F, Grendár M. Hybrid Artificial Intelligence Solution Combining Convolutional Neural Network and Analytical Approach Showed Higher Accuracy in A-lines Detection on Lung Ultrasound in Thoracic Surgery Patients Compared with Radiology Resident. Neuroendocrinology Letters. 2024;45(3).
Lukacova E, Burjanivova T, Podlesniy P, Grendar M, Turyova E, Kasubova I, Laca L, Mikolajcik P, Kudelova E, Vanochova A, Miklusica J. Hypermethylated GRIA4, a potential biomarker for an early non-invasive detection of metastasis of clinically known colorectal cancer. Frontiers in Oncology. 2023 Jul 5;13:1205791.
Kubáňová L, Bielik V, Hric I, Ugrayová S, Šoltys K, Rádiková Ž, Baranovičová E, Grendár M, Kolisek M, Penesová A. Gut microbiota and serum metabolites in individuals with class III obesity without type 2 diabetes Mellitus: pilot analysis. Metabolic Syndrome and Related Disorders. 2023 Jun 1;21(5):243-53.
Holubekova V, Loderer D, Grendar M, Mikolajcik P, Kolkova Z, Turyova E, Kudelova E, Kalman M, Marcinek J, Miklusica J, Laca L. Differential gene expression of immunity and inflammation genes in colorectal cancer using targeted RNA sequencing. Frontiers in Oncology. 2023 Oct 5;13:1206482.
Turyova E, Mikolajcik P, Grendar M, Kudelova E, Holubekova V, Kalman M, Marcinek J, Hrnciar M, Kovac M, Miklusica J, Laca L. Expression of OCT4 isoforms is reduced in primary colorectal cancer. Frontiers in Oncology. 2023 Jun 20;13:1166835.
Grofik M, Cibulka M, Oleksakova J, Sivak S, Cierny D, Tatarkova Z, Grendar M, Nosal V, Ruzinak R, Kurca E, Kolisek M. Oxidative stress parameters and their relation to motor subtype of Parkinson’s disease and levodopa treatment status. General Physiology & Biophysics. 2023 Jan 1;42(1).
Blichárová A, Tancoš V, Benetinová Z, Verbóová Ľ, Grendár M, Mazuráková A, Plank L, Mechírová E. Programmed death ligand-1 expression and its association with the degree of differentiation and the presence of necrosis in non-small cell lung carcinoma. Pathology-Research and Practice. 2023 Feb 1;242:154296.
Bielik V, Hric I, Ugrayová S, Kubáňová L, Putala M, Grznár Ľ, Penesová A, Havranová A, Šardzíková S, Grendar M, Baranovičová E. Effect of high-intensity training and probiotics on gut microbiota diversity in competitive swimmers: randomized controlled trial. Sports medicine-open. 2022 Dec;8(1):64.
Brunclikova M, Simurda T, Zolkova J, Sterankova M, Skornova I, Dobrotova M, Kolkova Z, Loderer D, Grendar M, Hudecek J, Stasko J. Heterogeneity of genotype–phenotype in congenital hypofibrinogenemia—a review of case reports associated with bleeding and thrombosis. Journal of Clinical Medicine. 2022 Jan;11(4):1083.
Kudelova E, Holubekova V, Grendar M, Kolkova Z, Samec M, Vanova B, Mikolajcik P, Smolar M, Kudela E, Laca L, Lasabova Z. Circulating miRNA expression over the course of colorectal cancer treatment. Oncology Letters. 2022 Jan;23(1):18.
Kantorová E, Hnilicová P, Bogner W, Grendár M, Grossmann J, Kováčová S, Hečková E, Strasser B, Čierny D, Zeleňák K, Kurča E. Neurocognitive performance in relapsing-remitting multiple sclerosis patients is associated with metabolic abnormalities of the thalamus but not the hippocampus–GABA-edited 1H MRS study. Neurological Research. 2022 Jan 2;44(1):57-64.
Cibulka M, Brodnanova M, Grendar M, Necpal J, Benetin J, Han V, Kurca E, Nosal V, Skorvanek M, Vesely B, Stanclova A. Alzheimer’s disease-associated SNP rs708727 in SLC41A1 may increase risk for Parkinson’s disease: report from enlarged Slovak study. International journal of molecular sciences. 2022 Jan 29;23(3):1604.
Lipták P, Banovcin P, Rosoľanka R, Prokopič M, Kocan I, Žiačiková I, Uhrik P, Grendar M, Hyrdel R. A machine learning approach for identification of gastrointestinal predictors for the risk of COVID-19 related hospitalization. PeerJ. 2022 Mar 21;10:e13124.
Mersakova S, Janikova K, Kalman M, Marcinek J, Grendar M, Vojtko M, Kycina R, Pindura M, Janik J, Mikolajcik P, Gabonova E. Cancer stem cell marker expression and methylation status in patients with colorectal cancer. Oncology Letters. 2022 May 27;24(1):231.
Vorčák M, Sýkora J, Ďuríček M, Bánovčin P, Grendár M, Zeleňák K. Endovascular treatment of gastrointestinal hemorrhage. Medicina. 2022 Mar 14;58(3):424.
Grendár M, Martínek P, Loderer D, Ondič O. CNHplus: the chromosomal copy number heterogeneity which respects biological constraints. BioRxiv. 2022 Oct 3:2022-09.
Visnovcova Z, Ferencova N, Grendar M, Ondrejka I, Olexova LB, Bujnakova I, Tonhajzerova I. Electrodermal activity spectral and nonlinear analysis-potential biomarkers for sympathetic dysregulation in autism. General Physiology & Biophysics. 2022 Mar 1;41(2).
Hanko M, Grendár M, Snopko P, Opšenák R, Šutovský J, Benčo M, Soršák J, Zeleňák K, Kolarovszki B. Random forest–based prediction of outcome and mortality in patients with traumatic brain injury undergoing primary decompressive craniectomy. World neurosurgery. 2021 Apr 1;148:e450-8.
Kolkova Z, Holubekova V, Grendar M, Nachajova M, Zubor P, Pribulova T, Loderer D, Zigo I, Biringer K, Hornakova A. Association of circulating miRNA expression with preeclampsia, its onset, and severity. Diagnostics. 2021 Mar 8;11(3):476.
Mikolka P, Curstedt T, Feinstein R, Larsson A, Grendar M, Rising A, Johansson J. Impact of synthetic surfactant CHF5633 with SP‐B and SP‐C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome. Physiological Reports. 2021 Jan;9(1):e14700.
Cigerova V, Adamkov M, Drahošová S, Grendar M. Immunohistochemical expression and significance of SATB2 protein in colorectal cancer. Annals of diagnostic pathology. 2021 Jun 1;52:151731.
Tonhajzerova I, Ondrejka I, Ferencova N, Bujnakova I, Grendar M, Olexova LB, Hrtanek I, Visnovcova Z. Alternations in the cardiovascular autonomic regulation and growth factors in autism. Physiological Research. 2021 Jun 2;70(4):551.
Nováková S, Danchenko M, Okajčeková T, Baranovičová E, Kováč A, Grendár M, Beke G, Pálešová J, Strnádel J, Janíčková M, Halašová E. Comparative proteomic and metabolomic analysis of human osteoblasts, differentiated from dental pulp stem cells, hinted crucial signaling pathways promoting osteogenesis. International Journal of Molecular Sciences. 2021 Jul 24;22(15):7908.
Vojtková J, Kolková Z, Motyková K, Kostková M, Suroviaková S, Grendár M, Bánovčin P. An association between fibrinogen gene polymorphisms and diabetic peripheral neuropathy in young patients with type 1 diabetes. Molecular Biology Reports. 2021 May;48(5):4397-404.
Kantorová E, Hnilicová P, Bogner W, Grendár M, Čierny D, Hečková E, Strasser B, Ružinák R, Zeleňák K, Kurča E. Positivity of oligoclonal bands in the cerebrospinal fluid predisposed to metabolic changes and rearrangement of inhibitory/excitatory neurotransmitters in subcortical brain structures in multiple sclerosis. Multiple Sclerosis and Related Disorders. 2021 Jul 1;52:102978.
Kertys M, Grendar M, Horak V, Zidekova N, Skalnikova HK, Mokry J, Halasova E, Strnadel J. Metabolomic characterisation of progression and spontaneous regression of melanoma in the melanoma-bearing Libechov minipig model. Melanoma Research. 2021 Apr 1;31(2):140-51.
Miertová M, Bóriková I, Tomagová M, Madleňák J, Grendár M, Barnau A. Risk factors of falling among hospitalized patients with neurological disease–post-fall analysis. Medical Studies/Studia Medyczne. 2021 Jan 1;37(1):16-24.
Dzian A, Malik M, Hamada L, Skalicanova M, Zelenak K, Stevik M, Grendar M. Lung ultrasound could reduce X-ray after major lung resection. Bratislavske Lekarske Listy. 2021 Jan 1;122(12):871-5.
Mikolajcik P, Lasabova Z, Loderer D, Grendar M, Kalman M, Kasubova I, Lucansky V, Wiederhold AJ, Marcinek J, Burjanivova T, Kudelova E. Detection of therapeutically relevant and concomitant rare somatic variants in colorectal cancer. Neoplasma. 2021 Nov 1;68(6):1331-40.
Mazúchová L, Kelčíková S, Maskalová E, Malinovská N, Grendár M. Mother-infant bonding and its associated factors during postpartum period. KONTAKT-Journal of Nursing & Social Sciences related to Health & Illness. 2021 Apr 1;23(2).
Malík, M., Dzian, A., Skaličanová, M., Hamada, Ľ., Zeleňák, K. and Grendár, M. (2020). Chest ultrasound can reduce the use of X-ray in postoperative care after thoracic surgery. The Annals of Thoracic Surgery. https://doi.org/10.1016/j.athoracsur.2020.10.019
The result of the EU-funded BioMed Martin project is a revolutionary research center that develops new diagnostic and therapeutic methods and at the same time strengthens cooperation between the city of Martin and the Žilina Region in Slovakia.